胰岛素的受体及作用机制 INSULIN INSULIN RECEPTOR GLUCOSE UPTAKE PLASMA MEMBRANE GLUT4 translocation Sh2 VR p85)p110 Dissociation TC10 OS GTP PI3-K RAFRAS GLUT4 mTOR inactive Vesicle MEK DGSK3 active Forkhead PROTEIN elF2 transcripti ERK/MARK SYNTHESIS active actors PATHWAY Glycogen Synthase PROTEIN INHIBITION of SYNTHESIS GLYCOGEN GLUCONEOGENESIS SYNTHESIS三、胰岛素的受体及作用机制