§1| ntroduction Background for New Methodology Modern natural science methodology is mainly based on matter and energy. Even though matter and energy are still necessitate factors in information system, yet the characteristic feature of information systems, particularly the complex ones, is neither matter nor energy, but information. Without information the complex information systems like brain and intelligent life, cannot be understood§1 Introduction Background for New Methodology Modern natural science methodology is mainly based on matter and energy. Even though matter and energy are still necessitate factors in information system, yet the characteristic feature of information systems, particularly the complex ones, is neither matter nor energy, but information. Without information, the complex information systems, like brain and intelligent life, cannot be understood