、α-氢酸性与烯醇、烯醇负离子形成 2 Formation of enolate LDA lithium diisopropylamide -a strong base but a poor nucleophile - all carbonyl compound is converted to enolate prepared by buli with(ch3)2CHNHCH(CH3) CH3 CH3 CH3 CH3 THF CH3 CHNHCHCH3 CH3 CH2CH2CH2Li 78°C CH3CHNCHCH3 CH3 CH2CH2CH diisopropylamine butyllithium lithium diisopropylamide butane pKa=35 LDA Ka-50一、α - 氢酸性与烯醇、烯醇负离子形成 2、Formation of Enolate LDA —— lithium diisopropylamide —— a strong base but a poor nucleophile —— all carbonyl compound is converted to enolate —— prepared by BuLi with (CH3)2CHNHCH(CH3)2