9. 1.4.6 Macrophage Properties Tissue Iniury Oxygen metabolites Cytokines IL-1. TNF Eicosanoids FGF PDGF Cytokines TGF angiogenesis factor 9. 1.4.7 Increased Activities Associated with"Activated"Macrophages Bacteriocidal activity Tumoricidal activity Chemotaxis Endocytosis Secretion of biologically active products 9. 1.4.8 Life Spans of Phagocytes PM MNS: days Macrophages: monocytes circulate in the periheral blood 24-72 hours macrophages survive in tissue from months to years Multinucleated Foreign Body Giant Cells: survive in tissue from months to?9.1.4.6 Macrophage Properties Tissue Injury Oxygen metabolites Proteases Eicosanoids Cytokines Fibrosis Cytokines – IL-1, TNF – FGF, PDGF – TGF-� – angiogenesis factor 9.1.4.7 Increased Activities Associated with "Activated" Macrophages Bacteriocidal activity Tumoricidal activity Chemotaxix Endocytosis Secretion of biologically active products 9.1.4.8 Life Spans of Phagocytes PMNs: days Macrophages: monocytes circulate in the periheral blood 24-72 hours; macrtophages survive in tissue from months to years Multinucleated Foreign Body Giant Cells: survive in tissue from months to ?