ACYCLOVIR: Mechanisms Step 2 Then host enzymes(kinases)work conversion of Acyclovir-MP to di-and Acyclovir-MP triphosphate derivatives Acyclovir-TP is incorporated into DNA Host kinases no 3-hydroxyl-elongation is terminated and remains bound to dna polymerase causing its inhibition Acyclovir-DP Acyclovir-TP Acvclovir-TP 3 5 DNA polymerase StopACYCLOVIR: Mechanisms • Then host enzymes (kinases) work – conversion of Acyclovir -MP to di- and triphosphate derivatives. • Acyclovir-TP is incorporated into DNA – no 3'-hydroxyl – elongation is terminated and remains bound to DNA polymerase causing its inhibition. Acyclovir-DP Acyclovir-TP Host kinases Acyclovir-MP Step 2 3’-------------Acyclovir-TP 3’-----------------------------------------5’ DNA polymerase Stop