1/26/2016 Penetration into the Host Cell Cytoskeleton-the Cytoskeleton movers and shapers in the cell Invasins Animal cell with c -Surface proteins produced by bacteria that (gre actin filaments(red),and the rearrange actin filaments of the cytoskeleton nucleus (blue). Cause membrane ruffling Salmonella strains and Escherichia coli Some pathogens use actin to move from one cell to the next Shigella and Listeria as a re ce Motorized tail of actin moving the bacteria in the cell. Listeria species and Shigella Membrane ruffling is the result of disruptionm species uses actin tails to of the cytoskeleton of the host cell. penetrate neighboring cells.1/26/2016 8 Penetration into the Host Cell Cytoskeleton Invasins – Surface proteins produced by bacteria that rearrange actin filaments of the cytoskeleton • Cause membrane ruffling • Salmonella strains and Escherichia coli S th ti t f ll Some pathogens use actin to move from one cell to the next – Shigella and Listeria Animal cell with cytoskeleton stained microtubules (green) Cytoskeleton – the movers and shapers in the cell stained microtubules (green), actin filaments (red), and the nucleus (blue). Salmonella entering intestinal epithelial cells as a result of ruffling. Flagella Salmonella typhimurium Ruffling of host cell plasma membrane Membrane ruffling is the result of disruption of the cytoskeleton of the host cell. Motorized tail of actin moving th b t i i th ll the bacteria in the cell. Listeria species and Shigella species uses actin tails to penetrate neighboring cells