Multiple vagal afferent nerve subtypes innervate the airways and lungs NK receptor antagonists GABA-B agonists o-agc u-agonists NMDA glutamate antagonists Cortical neurons Tractus Placebo Solitarius CNS Brainstem channel blockers afferent neurons ′ otor neurons Respiratory Musdes Na1.7 blockers TRPV1 antagonists ungs RSD931 TRPA1 antagonists TRaNt Cough S As-fibers Bronchoconstriction Oedema Environmental imtants: SO, Ozone, Toluene Disocyanat Mucus secretion Inflammation Antitussive drugs--past, present, and future. Pharmacol Rev 2014 Mar 26: 66(2): 468-512Antitussive drugs--past, present, and future. Pharmacol Rev. 2014 Mar 26;66(2):468-512. Multiple vagal afferent nerve subtypes innervate the airways and lungs