Wittig反应举例 Ph3P oo NaCH,SCH (1)cH3 Ph2PCh?l Ph2P一CH 2 Wittig试剂 CH2 反应有选择性, 酯基不受影响 CH30--CCH2CH2COCH CH PhP一cH 2 CH3O CCH2 CH2 COCH3 Witt试剂 (1 Ph?P HcHO (3)Br-CH2 CO2Et PhP一cHco (2)NaOH Wittig试剂 Co2Et Z-isomer◼ Wittig反应举例 (1) (2) (3) 反应有选择性, 酯基不受影响 CH3 I Ph3P Ph3PCH3 I O Ph3P CH2 O CH2 Ph3P CH2 CH3O CCH2CH2COCH3 O CH3O CCH2CH2COCH3 CH2 PhCHO Ph3P CHCO2Et (1) Ph3P Br CH2CO2Et (2) NaOH C C Z-isomer NaCH2SCH3 O O H H Ph CO2Et Wittig 试剂 Wittig 试剂 Wittig 试剂