Section C: Consulting(50%) 1. Mr a is 45-year-old, and his wife is 38-year-old. Now Mrs ais pregnant, and the prenatal diagnosis showed Mrs. a was infected with Toxoplasma. Mr a also got some information from website, which shows a woman with age above 35 is easy to have Down syndrome baby. They are very worry about their baby, and come to see you, the consulter. Mr a ask: If our baby will have some birth defect? 2. Mr B(34-year-old )suspected he had got diabetes because he had some symptoms recently, such as thirst and weight loss. His grandfather, his father and 2 uncles are all the patients of diabetes, and his father has to use insulin every day. Please consult for him. Meanwhile, he also want to know his risk of hypertension, because his grandma has hypertension, but not severe 3. Mrs C(28-year-old) is a patient of lHON, and her husband (32-year-old) is a patient of Duchenne Muscular Dystrophies(DMD ).They p lan to have a baby Now they need your help, please consult for them 4. Mrs D is pregnant with her fifth child. She tells you that her eldest son who has cystic fibrosis(CF), and died aged 20 of a resp iratory infection The couple and their three other children are not affected with this condition. She worried the fetus may have CF. Please draw their pedigree and analyze it for Mrs dSection C: Consulting (50%) 1. Mr A is 45-year-old, and his wife is 38-year-old. Now Mrs Ais pregnant, and the prenatal diagnosis showed Mrs.A was infected with Toxoplasma. Mr A also got some information from website, which shows a woman with age above 35 is easy to have Down syndrome baby. They are very worry about their baby, and come to see you, the consulter. Mr A ask: “If our baby will have some birth defect? ” 2. Mr B(34-year-old) suspected he had got diabetes because he had some symptoms recently, such as thirst and weight loss. His grandfather, his father and 2 uncles are all the patients of diabetes, and his father has to use insulin every day. Please consult for him. Meanwhile, he also want to know his risk of hypertension, because his grandma has hypertension, but not severe. 3. Mrs C(28-year-old) is a patient of LHON, and her husband(32-year-old) is a patient of Duchenne Muscular Dystrophies (DMD).They plan to have a baby. Now they need your help, please consult for them. 4. Mrs D is pregnant with her fifth child. She tells you that her eldest son, who has cystic fibrosis (CF), and died aged 20 of a respiratory infection. The couple and their three other children are not affected with this condition. She worried the fetus may have CF. Please draw their pedigree and analyze it for Mrs D