1) Acute epidemical diseases 2) Cardiovascular diseases 3) Hemological diseases 4) Nutrition defect:VitC、K、 P or calciun 5) Liver, kidney diseases and rheumatic fever 6) Poison: phosphorus, mercury, arsenic, benzene 7 Osler's disease hemorrhagic familial telangiectasia 8) Endocrinic imbalance1） Acute epidemical diseases 2） Cardiovascular diseases 3） Hemological diseases 4） Nutrition defect：VitC、K、P or calcium 5） Liver, kidney diseases and rheumatic fever 6） Poison ：phosphorus, mercury, arsenic, benzene 7） Osler’s disease hemorrhagic familial telangiectasia 8） Endocrinic imbalance