H pylon cag Pilu Ra as Grb2Y Cortactin P Raf Src-- 小← PTPases Mek Csk SH2 F-actin MAPK (ERK) Cytoskeleton Scattering(AGs) Proliferation(MDCK) YAP SHP/- Hummingbird genotype(AGs pl ↑ Apoptosis(AGS)