Allo-Antigens in Inbread Strains of Mice Al10-Antigens 888888888888888888888888 Allo-Antigen embrane 88886888888888888688888 Ramdomly breeding colonies(all mice allo-ontigens) Inbreeding (brother sister mating)leads to homogeneity and a single allele becomes fixed in the population.Several 100 different inbred strains of mice have been developed (syn are produced by selective breeding,and repeated back crossing.Congenic strains are designated by the abbreviation of the background strain and donor strain separated by a period.Thus,an A.B mouse represents a congenic strain carrying background genes of the A strain a homozygous pair of histocompatibility genes derived from the B strain.With the dev lopment of inbred mice,congenic strains. and mutated strains of mice,genetic differences could be detected by immunological analysis of allo-antigens. With the development of inbred,congenic,and mutated strains of mice,genetic differences could be detected by immunological analysis of the allo-antigen or gene products.Cell-surface allo-antigens could be identified by a variety of techniques employing specific antibodiesor effector ce (lymphocytes).For example,cells from one inbred strain (donor)that processed an allo-antigen of interest might be given to another strain (recipient)no possessingInbreeding (brother sister mating) leads to homogeneity and a single allele becomes fixed in the population. Several 100 different inbred strains of mice have been developed (syngeneic strains). It is now possible to produce mice that only differ by a few genes (congenic strains) or single gene (coisogenic strain). Congenic strains are produced by selective breeding, and repeated back crossing. Congenic strains are designated by the abbreviation of the background strain and donor strain separated by a period. Thus, an A.B mouse represents a congenic strain carrying background genes of the A strain a homozygous pair of histocompatibility genes derived from the B strain.With the development of inbred mice, congenic strains, and mutated strains of mice, genetic differences could be detected by immunological analysis of allo-antigens. With the development of inbred, congenic, and mutated strains of mice, genetic differences could be detected by immunological analysis of the allo-antigen or gene products. Cell-surface allo-antigens could be identified by a variety of immunological techniques employing specific antibodies or effector cells (lymphocytes). For example, cells from one inbred strain (donor) that processed an allo-antigen of interest might be given to another strain (recipient) no possessing