Shigellosis Shigella 。 Shigella spp. producing Shiga Epithelial cells lining intestinal tract toxin ·Shiga toxin causes Shigella enter an epithelial cell inflammation and bleeding Shigella multiply inside the cell Shigella invade neighboring epithelial cells, thus avoiding immune defenses An abscess forms as epithelial cells are killed by the infection.The bacteria rarely spread in the bloodstream. Mucosal abscess Figure 25.8 Shigellosis Figure 25.8 • Shigella spp. producing Shiga toxin • Shiga toxin causes inflammation and bleeding