Discussion Stroke induction Stroke induction blocking peptide D DAPKl only mediating neuron’ s pathologic function, without affecting the normal NMD physiologic function Blocking peptide New targeting stroke therapy: DAPK1-NMDA Dcas receptor interaction DAPKI-specific inhibitors or Neuronal death Cell survival and antagonists Protection from stroke damage Figure 6. Youming Lu, et al. DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke, Cell, VoL. 140(2): 222-234, 2010Discussion  DAPK1 only mediating neuron’s pathologic function, without affecting the normal physiologic function  New targeting stroke therapy: DAPK1-NMDA receptor interaction  DAPK1-specific inhibitors or antagonists Figure 6. Youming Lu, et al. DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke, Cell, Vol.140(2):222-234, 2010