WNT→Frizzled→Disheveled Anti-growth factors (e.g.TGFB) GSK-3B APC TCF TGFBR Cells(E-Cadherin B-Catenin B-Catenin:TCF p16 CdC42→P13K---Rac-- ECM+Integrins。 中FAK→Cas→CNT、 Cycl D:CDK4p15-------Smads Src ⊥ Rb HPV E7 Fyn PLC p27---- E2Fs NF1 Mos MKKs JNKs Jun Cycl E:CDK2-p21← Growth Factors→FT○→ ↓ Grb2 DNA damage (e.g.TGFa) SOS +Ras+Raf-MEK→MAPK→MAPK—+EIK-Fos→ Changes Cell sensor Mad:Max in Gene Proliferation Abl MEKK (Cell Cycle) MyC:Max Expression p53 Hormones Cdc42→Rac-+Rho (e.g.Bombesin)(7-TMR G-ProtAd Cycl-PKA- CREB →ARF-MDM2 (e.g.Estrogen) NHR (e.g.ER) PKC NF-xB NF-kB- Mitochondrla Stat 3,5 Survival Factors+R☒、→pI3K→At→Aka-HlkB Cell Death -Bel 2 (e.g.1GF1) (Apoptosis】 Caspase 8 FADD Stat 3,5 PTEN Caspase 9 FAP-Fas Cytochrome C stat3,5-----◆Bel XL Bcl2 Decoy R) Mitochondria Bid Death Jaks Factors -Bim,etc (e.g.FasL) 、sensor Cytokine R Cytokines (c.g.L-3/6)