The impact of pregnancy on DM The first half of pregnancy 1. Relative insulin sensitivity: insulin requirementy Morning sickness: hypoglycemia The latter half of pregnancy 1. Increased insulin resistance: placental hormones 2. Intake intrapartum: hypoglycemia 3. Postpartum: placental hormones -hypoglycemiaThe impact of pregnancy on DM • The first half of pregnancy 1. Relative insulin sensitivity: insulin requirement↓ 2. Morning sickness: hypoglycemia • The latter half of pregnancy 1. Increased insulin resistance: placental hormones↑ 2. Intake↓intrapartum: hypoglycemia 3. Postpartum: placental hormones↓→hypoglycemia