Transmission patterns HorzontalTransmission: Direct person-to person spread Verticaltransmission: Relies on PerSiSTe cE of the agent to transfer infection from parents to offspring. Several forms of vertical transmission can be distinguished: 1 Neonatalinfection at birth, e.g. gonorrhoea AIDS 2. Infection in utero e.g. syphilis, CMV, Rubella CCRSLAIDS 3. Germ line infection -via ovum or spermTransmission patterns • Horizontal Transmission: Direct person-to￾person spread. • Vertical Transmission:Relies on PERSISTENCE of the agent to transfer infection from parents to offspring. Several forms of vertical transmission can be distinguished: • 1.Neonatal infection at birth, e.g. gonorrhorea, AIDS. • 2.Infection in utero e.g. syphilis, CMV, Rubella (CRS), AIDS. • 3. Germ line infection - via ovum or sperm