Ratification of the u.s Constitution was supported by Federalists, who argued in favor of the ratification and supported a strong central government was opposed by the anti-Federalists who opposed a strong central government and argued for a bill of rightsRatification of the U.S. Constitution : • was supported by Federalists, who argued in favor of the ratification and supported a strong central government. • was opposed by the Anti-Federalists, who opposed a strong central government and argued for a Bill of Rights