Anti-infectives A∥ rights re served Structure-toxicity relationships Influence Phototoxicity and Genetic Toxicity Metal Rinding and chelating site For Phototoxicity Controls interactions with CH3>>H>NH2 antiacids, milk iron supplements Most divalent metals Ca*. Fe++ Zn++ or Genetic Toxicity Effect of F on sidc effect reduce oral absorption CH3>NH>F profile has not been reported R F C-OH Controls gaba binding maior NSAID Interaction Maior). No side effects associated with Maior). genetic Toxicity尽7 R .2 this position For GABA Binding pip>pyrp>subst pip or pyrr For Nsaid interaction pip>>pymsubst pip or pyrr Phototoxicity major For Theophyline Interaction:// and Genetic Toxicity Controls Theophylline pyrr2pip>subst pyrr or pip Minor effect on Interaction and genetic Toxicity For Genetic Toxicity NSAID interactions For Theophylline Interaction pyrr>>pip>subst pyr >subst pip CESCC-NCH)COM, cce For Ge h CH3CH2>2, 4-diFPh>FCH, CH2- CP>CCL>COMe>N>CH >2, 4-diFPh CH2CH PHARMACEU NDUSTRYAnti-infectives All rights re served Structure-toxicity relationships