How AVCR1 works ONTROL SM-FKBP12 cvR1 SM-FKBP12………ACVR1(R206H ⊥ BMP Basally Leaky Signaling BMP Signaling Blocked in Absence of Ligand ACVR1 ACVR1(R206H) ↓↓↓ BMP per-responsive BMP Signaling (Kaplan et al. 2008) in Presence of LigandHow AVCR1 works (Kaplan et al. 2008)