version date 1 December 2006 [6] M. Suwalsky, I. Sanchez, M. Bagnara, C P. Sotomayor, Interaction of Antiarrhythmic Drugs with Model Membranes, Biochim. Biophys. Acta(1994)1195, 189-196 [7 M. Suwalsky, P. Hernandez, F. Villena, F. Aguilar, C.P. Sotomayor, The Anticancer Drug Adriamycin Interacts with the Human Erythrocyte Membrane, Z Naturforsch (1999,54c,271-277 8 M. Suwalsky, P. Hernandez, F. Villena, C P. Sotomayor, The Anticancer Drug Chlorambucil Interacts with the Human Erythrocyte Membrane and Model Phospholipid Bilayers, Z. Naturforsch. (1999)54c, 1089-1095 [9 M.P. Sheetz, S.J. Singer. Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug- Erythrocyte Induced Interactions. Proc. Natl. Acad. Sci. USA (1974)71,4457-4461 Dr. Mario Suwalsky nsuwalsk@udec cl High standards in safety measures should be maintained in all work carried out in Medicinal Chemistry laboratories The handling of electrical instruments, heating eleme glass materials dissolvents and other inflammable materials does not present a problem if the supervisor s instructions are carefully followed This document has been supervised by Prof. Mario Suwalsk (msuwalsk@udec cl) who has informed that no special risk (regarding toxicity, inflammability, explosions), outside of the standard risks pertaining to a Medicinal Chemistry laboratory exist when performing this exercise If your exercise involves any special risks, please inform the editor <www.iupac.org/publications/cd/medicinalchemistry/>7 [6] M. Suwalsky, I. Sánchez, M. Bagnara, C.P. Sotomayor, Interaction of Antiarrhythmic Drugs with Model Membranes, Biochim. Biophys. Acta (1994) 1195, 189-196. [7] M. Suwalsky, P. Hernández, F. Villena, F. Aguilar, C.P. Sotomayor, The Anticancer Drug Adriamycin Interacts with the Human Erythrocyte Membrane, Z. Naturforsch. (1999), 54c, 271-277. [8] M. Suwalsky, P. Hernández, F. Villena, C.P. Sotomayor, The Anticancer Drug Chlorambucil Interacts with the Human Erythrocyte Membrane and Model Phospholipid Bilayers, Z. Naturforsch. (1999) 54c, 1089-1095. [9] M.P. Sheetz, S.J. Singer. Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Induced Interactions. Proc. Natl. Acad. Sci. USA (1974) 71, 4457-4461. Dr. Mario Suwalsky msuwalsk@udec.cl. High standards in safety measures should be maintained in all work carried out in Medicinal Chemistry Laboratories. The handling of electrical instruments, heating elements, glass materials, dissolvents and other inflammable materials does not present a problem if the supervisor’s instructions are carefully followed. This document has been supervised by Prof. Mario Suwalsky (msuwalsk@udec.cl) who has informed that no special risk (regarding toxicity, inflammability, explosions), outside of the standard risks pertaining to a Medicinal Chemistry laboratory exist when performing this exercise. If your exercise involves any “special” risks, please inform the editor. <www.iupac.org/publications/cd/medicinal_chemistry/> version date: 1 December 2006