Renal tubule injury Renal tubule ec necrosis Basement membrane broken down Loss of tubule integrity Dead and Filtered protein Backleak of original urine detached ECs (HB or MB) into renal interstitium Cast formation Interstitial edema formation Tubule obstruction Oppressing pression renal tubule renal capillary Intracapsular pressure Aggravate Aggravate Effective filtration p\ tubule obstruction renal ischemia GFR→ Oliguria 2929 Renal tubule EC necrosis Basement membrane broken down Oliguria Oppressing Oppression renal tubule renal capillary Interstitial edema formation Backleak of original urine into renal interstitium Loss of tubule integrity Dead and detached ECs Filtered protein (HB or MB) Cast formation Tubule obstruction Intracapsular pressure  GFR  Renal tubule injury Effective filtration p  Aggravate Aggravate tubule obstruction renal ischemia