NiCl2/CrCl Coupling Cont Problem: Reaction didnt always work. The success of the Cr(ll) coupling depended on the batch of the Crc .Possible reasons: Quality of CrCl? NO! Homemade crcl, reagent didnt help .Possible contaminant in the CrCl? YYes! Kishi examined the effect of transition metals on the reaction and found that niCh had an effectNiCl2/CrCl2 Coupling Cont. Coupling Cont. • Problem: Problem: Reaction didn’t always work. The success Reaction didn’t always work. The success of the Cr(II) coupling depended on the batch of the of the Cr(II) coupling depended on the batch of the CrCl2. •Possible Reasons: Possible Reasons: • Quality of CrCl Quality of CrCl2? NO! Homemade CrCl Homemade CrCl2 reagent didn’t help reagent didn’t help •Possible contaminant in the CrCl Possible contaminant in the CrCl2? Yes!! Kishi examined the effect of transition metals Kishi examined the effect of transition metals on the reaction and found that on the reaction and found that NiCl2 had an effect. had an effect