Angiotensinogen Renin Bradykinin Angiotensin I Non-ACE-dependent pathways, ACE inhibitors e. g. chymase ACE Kininase Il) Inactive Angiotensin‖l Peptides I Bradykinin AT1 receptors AT2 receptors receptors AT 1 receptor antagonists Vasoconstriction Sympathetic stimulation Nitric oxide Cellular hypertrophy Prostacyclin Aldosterone Renovascular effects