③盐酸维拉帕米的合成 HO (CH3)2SO4、HCHO NaCN CN (CH3)2CHBr H3CO NaOH HCI CHaCOCHa HaCo 1 HgCO NH2 H3C、CH3 H3C CH3 Br入Cl CN H3CO H3CO CN H.CO 2 HaCO CH3 CH3 H3CO、HsC CN CN CH3 OCH3 (1)HCHO/HCOOH HaCo.HsC OCH3 (2)HCI ·H OCH3 H3CO OCH3 ③盐酸维拉帕米的合成 1 2 3 4 H3CO N H3CO OCH3 OCH3 CN CH3 CH3 H3C HCl HO H3CO (CH3)2SO4 NaOH HCHO HCl NaCN CH3COCH3 H3CO H3CO CN (CH3)2CHBr H3CO H3CO CN H3C CH3 Br Cl H3CO H3CO CN CH3 H3C H3CO H3CO NH2 H H3CO N H3CO OCH3 OCH3 CN CH3 H3C (1) HCHO/HCOOH (2) HCl Cl