(1)Multiple sequence alignment and progressive global alignment(ClustalW) Why produce a multiple sequence alignment? Conserved regions/domains are likely to represent regions that are essential for structure and function core of proteins A multiple sequence alignment is a starting point for an evolutionary(phylogenetic)analysis Using more than two sequences results in a more convincing alignment by revealing conserved regions in all of the sequences(1) Multiple sequence alignment and progressive global alignment (ClustalW) • Conserved regions/domains are likely to represent regions that are essential for structure and function - core of proteins • A multiple sequence alignment is a starting point for an evolutionary (phylogenetic) analysis • Using more than two sequences results in a more convincing alignment by revealing conserved regions in all of the sequences Why produce a multiple sequence alignment?