9s6 nature ARTICLES electronics https:/do1,org/10.1038/h41928-018-0116-y Three-dimensional integrated stretchable electronics Zhenlong Huang125,Yifei Hao139,Yang Lis,Hongjie Hu4,Chonghe Wang',Akihiro Nomoto', Taisong Pan2,Yue Gu4,Yimu Chen',Tianjiao Zhang',Weixin Li,Yusheng Lei',NamHeon Kim', Chunfeng Wang15,Lin Zhang',Jeremy W.Wards,Ayden Maralani,Xiaoshi Li,Michael F.Durstocks, Albert Pisano47,Yuan Lin2 and Sheng Xuv478* Stretchable electronics is an emerging technology that creates devices with the ability to conform to nonplanar and dynamic surfaces such as the human body.Current stretchable configurations are constrained to single-layer designs due to limited material processing capabilities in soft electronic systems.Here we report a framework for engineering three-dimensional inte- grated stretchable electronics by combining strategies in material design and advanced microfabrication.Our three-dimen- sional devices are built layer by layer through transfer printing pre-designed stretchable circuits on elastomers and creating vertical interconnect accesses using laser ablation and controlled soldering.Our approach enables a higher integration density on stretchable substrates than single-layer approaches and allows new functionalities that would be difficult to implement with conventional single-layer designs.Using this engineering framework,we create a stretchable human-machine interface testbed that is based on a four-layer design and offers eight-channel sensing and Bluetooth data communication capabilities. Nature Electronics,2018,1,473-480Nature Electronics, 2018, 1, 473–480