Myocardial blood flow parallels myocardial metabolism Metabolic signals are the principal determinants of O2 delivery to myocardium Resting: 60-80 ml/100g/min Exercise: 300-400 ml/100g/min O2 consumption 7-9 ml/100g/min is about 65-70% of o2 extraction Adenosine activates purinoceptors to induce vasodilation by lowing [Ca2+]Myocardial blood flow parallels myocardial metabolism • Metabolic signals are the principal determinants of O2 delivery to myocardium – Resting: 60-80 ml/100g/min – Exercise: 300-400 ml/100g/min – O2 consumption 7-9 ml/100g/min is about 65-70% of O2 extraction • Adenosine activates purinoceptors to induce vasodilation by lowing [Ca2+]i