国卢生 图上人生 Adhesives ④Fillers/diluents ©PVP Fillers are used to arrive at a tablet of ®Starch paste reasonable size when a drug forms a small Cellulose and its derivatives portion of the formula. ·MC Depending on the physiological conditions and ·HPC formulation,one needs a tablet of around 100 ·HPMC mg for ease of handling and administration, ·EC and therefore,fillers are used to increase bulk. ©MCC 国丝生一 图生一 ©Diluents ©Disintegrants ·Lactose ·Added to tablet formulations to facilitate ·Starch disintegration of the tablet .Microcrystalline cellulose(MCC) when it contacts water. ·Dicalcium phosphate ·Mannitol 国丝生 国生 ©Binders Mechanism of Disintegrants bind small drug or excipient particles together to form ·Swelling a granulate of a designed size range help the tablet to remain intact after compression. ·Capillary action be added as solution or dry powders ·Gas release ©Moistening agents RCOOH +NaHCO;-RCOONa+CO:+H2O .moisten the powder and induce its stickiness Heat of wetting Water or alcohol ·Enzymes 11 Shanghai Jiao Tong University Fillers/diluents • Fillers are used to arrive at a tablet of reasonable size when a drug forms a small portion of the formula. • Depending on the physiological conditions and formulation, one needs a tablet of around 100 mg for ease of handling and administration, and therefore, fillers are used to increase bulk. Shanghai Jiao Tong University Diluents • Lactose • Starch • Microcrystalline cellulose (MCC) • Dicalcium phosphate • Mannitol Shanghai Jiao Tong University Binders • bind small drug or excipient particles together to form a granulate of a designed size range • help the tablet to remain intact after compression. • be added as solution or dry powders Moistening agents • moisten the powder and induce its stickiness • Water or alcohol Shanghai Jiao Tong University Adhesives PVP Starch paste Cellulose and its derivatives • MC • HPC • HPMC • EC MCC Shanghai Jiao Tong University Disintegrants • Added to tablet formulations to facilitate disintegration of the tablet when it contacts water. Shanghai Jiao Tong University Mechanism of Disintegrants • Swelling • Capillary action • Gas release • Heat of wetting • Enzymes