CHAPTER 7: Chromosomes, chromatin, and the nucleosome 1. What is the cost (challenge)of compaction of DNA into chromosome? [De-compaction is required when DNA needs to be accessible by other proteins for cellular activities such as replication, transcription, 2. How the challenge could be resolved? TThe interaction between DNA and histones is dynamic, chromosome remodeling, chromosome modification 3. What are the advantage of the challenge? [Add a large layer of gene regulation1. What is the cost (challenge) of compaction of DNA into chromosome? [De-compaction is required when DNA needs to be accessible by other proteins for cellular activities such as replication, transcription. ] 2. How the challenge could be resolved? [The interaction between DNA and histones is dynamic, chromosome remodeling, chromosome modification] 3. What are the advantage of the challenge? [Add a large layer of gene regulation] CHAPTER 7: Chromosomes, chromatin, and the nucleosome