Proposed Liposome Classification (Cont.) ·MPS Uptake -Superior to subcutaneous where dose is concentrated in confined area>extracellular matrix cellular localization.local iritation,rapid entry into central compartment -Distributes dose to greater number of cells (volume)> MPS cells -Forms MPS "depot">slow re-release into central compartment resembles prolonged infusion Avoids peaks and associated adverse effects while maintaining AUC -Clinical benefit documented(Myocet,AmBisome) Proposed Liposome Classification (Cont.) ·MPS Avoid -Surface modification slows MPS uptake -Drug retained in liposome in plasma -Circulates for several days -Small enough to extravasate in tissues -Preferential uptake at sites with compromised endothelium -Drug released in tissue compartment8