HIV Infection Reverse Capsid transcriptase DNA Virus Two identical stands of RNA Retrovirus penetrates Host host cell. cell DNA of one of the host 5Mature cell's chromosomes retrovirus leaves host Reverse cell,acquiring transcriptase an envelope as it buds out. Identical Viral RNA 2Virion penetrates cell and its DNA is strands of RNA uncoated 4 Transcription of the provirus may also occur, Viral proteins producing RNA for new retrovirus genomes and RNA RNAthat codes for the retrovirus capsid and envelope proteins. 3 The new viral DNA is tranported into the host cell's nucleus and integrated as a provirus.The provirus may divide indefinitely with the Provirus host cell DNA. Figure 13.19 HIV Infection Figure 13.19 Retrovirus penetrates host cell. Virion penetrates cell and its DNA is uncoated The new viral DNA is tranported into the host cell’s nucleus and integrated as a provirus. The provirus may divide indefinitely with the host cell DNA. 1 2 3 DNA Transcription of the provirus may also occur, producing RNA for new retrovirus genomes and RNA that codes for the retrovirus capsid and envelope proteins. 4 Mature retrovirus leaves host cell, acquiring an envelope as it buds out. 5 Reverse Capsid transcriptase Virus Two identical + stands of RNA DNA of one of the host cell’s chromosomes Provirus Host cell Reverse transcriptase Viral RNA RNA Viral proteins Identical strands of RNA