6 PHARMACOEPIDEMIOLOGY adverse blood dys 1960 ntrolled investigations,including clinical i nduce this has reports of The ug marketin Sur app 1 to pe oday. In ad the igs used in late to 1938an 0E rted to the The ting Des 961 rld ex cted by the Na infamou with supp t fro a mild hypn tic. and hadn rugs in and ha of a A nge: gatio arts th miolog ases in the of ero the dr arke nide the u Kin thi 1968 th rga series of drug publication of a firs descriptive informatio is and ugs, and 11) of the egan a series of US and det of poor pr bing (see with all of thes he Us oht to have ite the on. the late 1960s. 1970n for d 990 have en a series maio dvers ropathy (SMON)was found to be ata in the early 1930 ational until In the 1970 o8 ould Thre the and in ital ue in re to aded to linical testir mid-1970 saw the dis tha the drug will hav the effec it synd om evidence Sub lol five was defined as 6 ate ing 980 the drug ticrynafen was noted to