河北医科大学药学院 Dorothy Crowfoot Hodgkin Dorothy Crowfoot Hodgkin Using X-ray crystallography to "see"atom -Penicillin,1945 C。 These achievements had an immense impact on che chemistry. Even More Important She. Early Interests of a"Gentle Genius".. Dorothy's remarkable personality Dorothy Hodgkin:Structure as Art From black art Worked to improve relations between East She liked to "think with her hands" Going bevond the limits... 热科研得诺，热学出相 Oxford graduation,1932 5 X-ray studies at Cambridg Ow Labat Oxford rheumatoid arthritis 天然药物化学教研室史清文教授 5 河北医科大学药学院 天然药物化学教研室 史清文教授 5 385 Dorothy Crowfoot Hodgkin 晶体王国之花 霍奇金(1910-1994) Went beyond “feasible limits” Figured out something organic chemists could not! Vitamin B12 Penicillin G Cholesterol Using X-ray crystallography to “see” atoms Dorothy Hodgkin，one of the outstanding scientists of the 20th century，solved the structures of ——Penicillin, 1945 ——Vitamin B12, 1954 ——Nobel Priz, 1964 ——Insulin, 1969 These achievements had an immense impact on chemistry, biochemistry and medical science, establishing the power of X-ray crystallography, and changing the practice of synthetic chemistry. Dorothy Crowfoot Hodgkin Even More Important She… • Reinvented crystallography – From black art scientific tool • Established use of molecular structure to explain biological function • Worked to improve relations between East and West • Interested in World Peace: • Is the “Cleverest woman in England” • Has been called “Gentle Genius” Dorothy’s remarkable personality Early Interests of a “Gentle Genius”… • Chemistry, especially crystals • Crystals – atoms arranged in regular and repeated pattern • “A diamond is a girl’s best friend!” • 16th Birthday Party: – Received X-ray crystallography book • Accepted to Oxford University in 1928 • On vacation, studied patterns of mosaic floors • “You’re finding what’s there and then trying to make sense of what you find.” Synagogue mosaic floor in Jerusalem. Dorothy Hodgkin: Structure as Art Rheumatoid arthritis never slowed her determined pursuit of science She liked to “think with her hands”… • Oxford graduation, 1932 • X-ray studies at Cambridge • PhD with J.D. Bernal 1934 • Own Lab at Oxford in 1934 Good News: Complex proteins could be analyzed Bad News: Diagnosed with rheumatoid arthritis 类风湿导致了手指严重扭曲 Going beyond the limits… • Took teaching job at Oxford. • Primitive lab in basement • Investigated sterols • Went beyond “feasible limits” • Figured out something organic chemists could not! • Victory Dance! Structure of Cholesterol 搞科研得诺奖，搞教学教出首相