Mechanisms Clinicopathologic Disease Target antigen of disease manifestations hemolytic anemia proteins(Rh blood group phagocytos(and Autoimmune Erythrocyte membrane Opsonization Hemolysis, anemia antigens, I antigen) of erythrocytes Autoimmune Platelet membrane Opsonization and Bleeding (idiopathic) proteins(gpllb: lla phagocytos thrombocytopenic integrin) of platelets purpura Pemphigus Proteins in intercellular Antibody-mediated Skin vesicles vulgarIs junctions of epidermal activation of proteases,(bullae) cells(epidermal cadherin) disruption of intercellular adhesions Goodpastures Noncollagenous protein Complement- and Nephritis. syndrome in basement membranes Fc receptor-mediated lung hemorrhages of kidney glomeruli and inflammation lung alveoli Acute rheumatic Inflammation Myocarditis fever macrophage activatio antigen Myasthenia gravis Acetylcholine receptor Antibody inhibits Muscle weakne acetycholine binding lysis down-modulates receptors Graves disease Thyroid-stimulating Antibody-mediated Hyperthyroidism (hyperthyroidism) hormone(TSH)receptor stimulation of TSH receptors Pernicious anemia Intrinsic factor of gastric Neutralization of Abnormal parietal cells intrinsic factor decreased absorption anemia 2 @ElsevierAbbas&Lichtman:BasicImmunologyUpdated2e-www.studentconsult.com Human antibody-mediated diseasesHuman antibody-mediated diseases