Rheumatic fever (RF) a This is a multisystem disease and an acute, often recurrent, inflammatory disease principally of children that generally follows a pharyngeal(but not skin) infection with group a beta-hemolytic streptococciRheumatic fever (RF) ◼ This is a multisystem disease and an acute, often recurrent, inflammatory disease principally of children that generally follows a pharyngeal(but not skin) infection with group A beta-hemolytic streptococci