Chronic myelogenous leukemia. CML ge 15-60 years Peak incidence: 40-50 years Clinical features 1. Onset is slow 2. nonspecific initial symptoms Easy fatigability, weakness, and weight loss 3. Extreme splenomegaly-+ infarct- paiAge 25-60 years Peak incidence : 40-50 years Clinical features 1. Onset is slow; 2. nonspecific initial symptoms Easy fatigability, weakness, and weight loss 3. Extreme splenomegaly infarct pains Chronic myelogenous leukemia, CML