D. A. Evans An Introduction to Frontier Molecular Orbital Theory-1 Chem 206 http://www.courses.fas.harvardedu/-chem206/ ■ Problem of the Day The molecule illustrated below can react through either Path A or Path B to i form salt 1 or salt 2. In both instances the carbonyl oxygen functions as the Chemistry 206 nucleophile in an intramolecular alkylation. What is the preferred reaction pat for the transformation in question Advanced Organic Chemist Lecture number 1 Path B Introduction to FMo Theory ■ Your Answer General Bonding considerations The H2 Molecule Revisited (Again!) a Donor& Acceptor Properties of Bonding Antibonding States L Hyperconjugation and"Negative"Hyperconjugation Anomeric and related Effects Reading Assignment for week A. Carey& Sundberg: Part A; Chapter 1 B. Fleming, Chapter 1&2 C Fukui, Acc. Chem. Res. 1971, 4, 57 D. O.J. Curnow J Chem. Ed. 1998. 75. 910 E J 1. Brauman. Science. 2002. 295 2245 Matthew d shair Wednesday, eptember 18, 2002D. A. Evans Chem 206 Matthew D. Shair Wednesday, September 18, 2002 http://www.courses.fas.harvard.edu/~chem206/ ■ Reading Assignment for week: A. Carey & Sundberg: Part A; Chapter 1 B. Fleming, Chapter 1 & 2 C. Fukui,Acc. Chem. Res. 1971, 4, 57. D. O. J. Curnow, J. Chem. Ed. 1998, 75, 910. E. J. I. Brauman, Science, 2002, 295, 2245. Chemistry 206 Advanced Organic Chemistry Lecture Number 1 Introduction to FMO Theory ■ General Bonding Considerations ■ The H2 Molecule Revisited (Again!) ■ Donor & Acceptor Properties of Bonding & Antibonding States ■ Hyperconjugation and "Negative" Hyperconjugation ■ Anomeric and Related Effects An Introduction to Frontier Molecular Orbital Theory-1 ■ Problem of the Day The molecule illustrated below can react through either Path A or Path B to form salt 1 or salt 2 . In both instances the carbonyl oxygen functions as the nucleophile in an intramolecular alkylation. What is the preferred reaction path for the transformation in question? + + Br – Br – 1 2 Path A Path B Br N H O Br O O Br N O H O N O H Br ■ Your Answer