Point Mutation Non-Dis junction LOH Loss of heterozygosity Chromosome Chromosome loss loss duplication wt l Rb Mutant Rb Recombination Interchromosomal Deletion Translocation Gene Conversion RecombinationPoint Mutation Non-Disjunction Chromosome loss & duplication Chromosome loss Recombination Deletion Interchromosomal Recombination Translocation Gene Conversion wt Rb Mutant Rb LOH - Loss of heterozygosity