Pathogenesis of HBV-hepatitis Immuno-injury v The host immune response to the virus is the main determinant of the outcome of infection v The hepatocyte damage result from the virus-infected cells by CD8+ cytotoxic T cells Cellular immune-mediated injury: when host immune response is in normal Acute hepatitis O Hyper-reactive Fulminant hepatitis ● Deficiency Chronic hepatitis ● TOlerance Health” carrier state Soluble immune-mediated injury is involved in-amm", not main mechanismCellular immune-mediated injury: when host immune response is--- ⚫ in Normal Acute hepatitis ⚫ Hyper-reactive Fulminant hepatitis ⚫ Deficiency Chronic hepatitis ⚫ Tolerance “Health” carrier state Pathogenesis of HBV-hepatitis : Immuno – injury Soluble immune-mediated injury is involved in-----, not main mechanism ✓The host immune response to the virus is the main determinant of the outcome of infection. ✓The hepatocyte damage result from the virus-infected cells by CD8+ cytotoxic T cells. 7