Antiarrhythmic Agents Vaughn-Williams Classification Class -Nat-channel blockers(direct membrane action) Class -Sympatholytic agents Class ll-Prolong repolarization Class IV- Cat+- channel blockers Purinergic agonists Digitalis glycosidesAntiarrhythmic Agents Vaughn-Williams Classification • Class I - Na+ - channel blockers (direct membrane action) • Class II - Sympatholytic agents • Class III - Prolong repolarization • Class IV- Ca++ - channel blockers • Purinergic agonists • Digitalis glycosides