Methyl Ketene Dimerization Me Zn 1 mol%amine Me Br THF,-78°C Br MeH Me OH LIAIH Me 20% yield Me Me uridine (R)98%ee (trimethyl quInine (S)93%ee Calter, M. A.J. Org. Chem. 1996, 61, 8006Methyl Ketene Dimerization Calter, M. A. J. Org. Chem. 1996, 61, 8006. O Br Me Br Zn O Me H O O Me Me LiAlH4 (S) 93% ee (R) 98% ee O Me Me OH O R3 N Me O Me 1 mol% amine THF, -78 °C * * quinidine (trimethylsilyl)quinine 20% yield * *