Selection Mutation Selection:Culture a naturally-occurring microbe that produces desired product Mutation:Mutagens cause mutations that might result in a microbe with a desirable trait ● Site-directed mutagenesis:Change a specific DNA code to change a protein Select and culture microbe with the desired mutation• Selection: Culture a naturally-occurring microbe that produces desired product • Mutation: Mutagens cause mutations that might result in a microbe with a desirable trait • Site-directed mutagenesis: Change a specific DNA code to change a protein • Select and culture microbe with the desired mutation Selection & Mutation