中国体育科技2019年(第55卷) 周雨青,刘星,马兰,2014药物成瘾的神经生物学机制研究[J]生 ropharmacology, 56: 177-185 命科学,26(6):593-602 KUJALA U M, KAPRIO J, ROSER J, 2007. Physical activity in ado- BAUER J, PEDERSEN A, SCHERBAUM N, et al., 2013. Craving lescence and smoking in young adulthood: A prospective twin cohort alcohol-dependent patients after detoxification is related to glutama- udy[ J].Addiction,102(7):1151-1157 tergic dysfunction in the nucleus accumbens and the anterior cingu- KULIG K, BRENER N D, MCMANUS T, 2003. Sexual activity and late cortex [J]. Neuropsychopharmacol, 38(8): 1401-1408. dolescents by category of physica BLUM K, BRAVERMAN E R. HOLDER J M, et al., 2000. Reward plus team sports participation []. Arch Pediatr Adolesc Med, 157(9): deficiency syndrome: A biogenetic model for the diagnosis and 905-912 treatment of impulsive, addictive, and compulsive behaviors [J] LYNCH WJ, PIEHL K B, ACOSTA G, et al., 2010. Aerobic exercise Psychoactive Drugs, 32(1): 1-112 attenuates reinstatement of cocaine-seeking behavior and associated BROWNRA, ABRANTES A M, READ J P, et al. 2010 A pilot study neuroadaptations in the prefrontal cortex [J]. Biol Psychiat, 68(8) of aerobic exercise as an adjunctive treatment for drug dependence j 77477 Men Health Phys Act, 3(1): 27-34 LYNCH W, ROBINSON A M. ABEL J, et al., 2017. Exercise as a CABRAL DA R, TAVARES VDO, DA COSTA K G, et al., 2018. TH Prevention for Substance Use Disorder: A Review of Sex differenc. benefits of high intensity exercise on the brain of a drug abuser [J] es and Neurobiological Mechanisms [J]. Curr Addict Rep, 4(4): Global J Health Sci, 10(6): 123 CHARTOFF E H, CARLEZON WAJR, 2014. Drug withdrawal con- MELIS M, SPIGA S, DIANA M, 2005. The dopamine hypothesis of ceptualized as a stressor [J]. Behav Pharmacol, 25(5-6):473-492 drug addiction: Hypodopaminergic state [J], Int rev neurobiol, 63: CORREIA C. BENSON T A, CAREY KB, 2005. Decreased sub stance use following increases in alternative behaviors: A prelimi- MILADI-GORJI H, RASHIDY-POUR A, FATHOLLAHI Y, 2012. nary investigation [J]. Addict Behav, 30(1): 19-27 Anxiety profile in morphine-dependent and withdrawn rats: Effect of De La GARZA R, YOON J H, THOMPSON-LAKE D G, et al., 2016. voluntary exercise[J] Physiol Behav, 105(2): 195-202 Treadmill exercise improves fitness and reduces craving and use of O DELL SJ, GALvEZ B A, BALL A J, et al., 2012. Running wheel cocaine in individuals with concurrent cocaine and tobacco-use dis. exercise ameliorates methamphetamine-induced damage to dopa- order[J]. Psychiat Res,245: 133-140 mine and serotonin terminals [J]. Synapse, 66(1):71-80 FISCHER-SMITH K D, HOUSTON AC W, REBEC G V, 2012. Dif- OZBURN A R, JANOWSKYAJ, CRABBE J C, 2015. Commonalities ferential effects of cocaine access and withdrawal on glutamate type and distinctions among mechanisms of addiction to alcohol and oth- I transporter expression in rat nucleus accumbens core and shell [J] er drugs [J]. Alcohol Clin Exp Res, 39(10):1863-1877 Neuroscience, 210: 333-339 PERETTI-WATEL P, GUAGLIARDO V, VERGER P, et al., 2003 GARDNER E L, 2002. Addictive potential of cannabinoids: The under- Sporting activity and drug use: Alcohol, cigarette and cannabis use lying neurobiology [J]. Chem Phys Lipids, 121(1-2): 267-290 among elite student athletes [J].Addiction, 98(9):1249-1256 GARDNER E L, 2011. Addiction and brain reward and antireward PETERSON A B, ABEL J M, LYNCH WJ, 2014a Dose-dependent pathways [J] Adv psychosom med, 30: 22 effects of wheel running on cocaine-seeking and prefrontal cortex GIRAULT JA, VALJENT E, CABOCHE J, et al., 2007. ERK2: A Bdnf exon IV expression in rats U]. Psychopharmacology, 231(7): logical and gate critical for drug-induced plasticity? [J]. Curr Opin 1305-1314 Pharmacol, 7(1): 77-85 PETERSON A B, HIVICK D P, LYNCH WJ, 2014b Dose-dependent GOLDSTEINR Z, VOLKOWND, 2002. Drug addiction and its effectiveness of wheel running to attenuate cocaine-seeking: impact nderlying neurobiological basis: Neuroimaging evidence for the of sex and estrous cycle in rats []. Psychopharmacology, 231(13): involvement of the frontal cortex [J]. Am J Psychiatry, 159(10): 2661-2670. 1642-1652 RAWSON R A, CHUDZYNSKI J, MOONEY L, et al. 2015 Impact KIM HD, CALL T, MAGAZU S, et al., 2017. Drug addiction and his- of an exercise intervention on methamphetamine use outcomes tone code alterations [J]. Adv Exp Med Biol, 978: 127-143 post-residential treatment care []. Drug Alcohol Depen, 156: 21-28 KIRKCALDY B D, SHEPHARD R J, SIEFEN R G, 2002. The rela- ROBERTS V, MADDISON R, SIMPSON C, et al., 2012. The acute ef- tionship between physical activity and self- image and problem be. fects of exercise on cigarette cravings, withdrawal symptoms, affect haviour among adolescents [J]. So Psych Psych Epid, 37(11):544- and smoking behaviour: Systematic review update and meta-analysis [J]. Psychopharmacology, 222(1):1-15 KOOB G F, VOLKOW N D, 2010. Neurocircuitry of addiction [J]. ROBISON L S, SWENSON S, HAMILTON J,et al.,2018.Exercise Neuropsychopharmacology, 35(1): 217-238. reduces dopamine DIR and s D2R in rats: Implications for KOYA E, UEJIMAJL, WIHBEY KA, et al. 2009 Role of ventral diction [J]. Med Sci Sports Exer, 50(8):1596-1602 medial prefrontal cortex in incubation of cocaine craving [J]. Neu- ROESSLER K. K, 2010. Exercise treatment for drug abuse-A danish中国体育科技2019年（第 55卷） 8 周雨青，刘星，马兰，2014.药物成瘾的神经生物学机制研究［J］.生 命科学，26（6）：593-602. BAUER J，PEDERSEN A，SCHERBAUM N，et al.，2013. Craving in alcohol-dependent patients after detoxification is related to glutama￾tergic dysfunction in the nucleus accumbens and the anterior cingu￾late cortex［J］. Neuropsychopharmacol，38（8）：1401-1408. BLUM K，BRAVERMAN E R，HOLDER J M，et al.，2000. Reward deficiency syndrome：A biogenetic model for the diagnosis and treatment of impulsive，addictive，and compulsive behaviors［J］. J Psychoactive Drugs，32（l）：1-112. BROWN R A，ABRANTES A M，READ J P，et al.，2010. A pilot study of aerobic exercise as an adjunctive treatment for drug dependence［J］. Men Health Phys Act，3（1）：27-34. CABRAL D A R，TAVARES V D O，DA COSTA K G，et al.，2018. The benefits of high intensity exercise on the brain of a drug abuser［J］. Global J Health Sci，10（6）：123. CHARTOFF E H，CARLEZON W A J R，2014. Drug withdrawal con￾ceptualized as a stressor［J］. Behav Pharmacol，25（5-6）：473-492. CORREIA C J，BENSON T A，CAREY K B，2005. Decreased sub￾stance use following increases in alternative behaviors：A prelimi￾nary investigation［J］. Addict Behav，30（1）：19-27. De La GARZA R，YOON J H，THOMPSON-LAKE D G，et al.，2016. Treadmill exercise improves fitness and reduces craving and use of cocaine in individuals with concurrent cocaine and tobacco-use dis￾order［J］. Psychiat Res，245：133-140. FISCHER-SMITH K D，HOUSTON A C W，REBEC G V，2012. Dif￾ferential effects of cocaine access and withdrawal on glutamate type 1 transporter expression in rat nucleus accumbens core and shell［J］. Neuroscience，210：333-339. GARDNER E L，2002. Addictive potential of cannabinoids：The under￾lying neurobiology［J］. Chem Phys Lipids，121（1-2）：267-290. GARDNER E L，2011. Addiction and brain reward and antireward pathways［J］. Adv psychosom med，30：22. GIRAULT J A，VALJENT E，CABOCHE J，et al.，2007. ERK2：A logical and gate critical for drug-induced plasticity?［J］. Curr Opin Pharmacol，7（1）：77-85. GOLDSTEIN R Z，VOLKOW N D，2002. Drug addiction and its underlying neurobiological basis：Neuroimaging evidence for the involvement of the frontal cortex［J］. Am J Psychiatry，159（10）： 1642-1652. KIM H D，CALL T，MAGAZU S，et al.，2017. Drug addiction and his￾tone code alterations［J］. Adv Exp Med Biol，978：127-143. KIRKCALDY B D，SHEPHARD R J，SIEFEN R G，2002. The rela￾tionship between physical activity and self-image and problem be￾haviour among adolescents［J］. So Psych Psych Epid，37（11）：544- 550. KOOB G F，VOLKOW N D，2010. Neurocircuitry of addiction［J］. Neuropsychopharmacology，35（1）：217-238. KOYA E，UEJIMA J L，WIHBEY K A，et al.，2009. Role of ventral medial prefrontal cortex in incubation of cocaine craving［J］. Neu￾ropharmacology，56：177-185. KUJALA U M，KAPRIO J，ROSE R J，2007. Physical activity in ado￾lescence and smoking in young adulthood：A prospective twin cohort study［J］. Addiction，102（7）：1151-1157. KULIG K，BRENER N D，MCMANUS T，2003. Sexual activity and substance use among adolescents by category of physical activity plus team sports participation［J］. Arch Pediatr Adolesc Med，157（9）： 905-912. LYNCH W J，PIEHL K B，ACOSTA G，et al.，2010. Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex［J］. Biol Psychiat，68（8）： 774-777. LYNCH W J，ROBINSON A M，ABEL J，et al.，2017. Exercise as a Prevention for Substance Use Disorder：A Review of Sex Differenc￾es and Neurobiological Mechanisms［J］. Curr Addict Rep，4（4）： 455-466. MELIS M，SPIGA S，DIANA M，2005. The dopamine hypothesis of drug addiction：Hypodopaminergic state［J］. Int rev neurobiol，63： 101. MILADI-GORJI H，RASHIDY-POUR A，FATHOLLAHI Y，2012. Anxiety profile in morphine-dependent and withdrawn rats：Effect of voluntary exercise［J］. Physiol Behav，105（2）：195-202. O’DELL S J，GALVEZ B A，BALL A J，et al.，2012. Running wheel exercise ameliorates methamphetamine-induced damage to dopa￾mine and serotonin terminals［J］. Synapse，66（1）：71-80. OZBURN A R，JANOWSKY A J，CRABBE J C，2015. Commonalities and distinctions among mechanisms of addiction to alcohol and oth￾er drugs［J］. Alcohol Clin Exp Res，39（10）：1863-1877. PERETTI-WATEL P，GUAGLIARDO V，VERGER P，et al.，2003. Sporting activity and drug use：Alcohol，cigarette and cannabis use among elite student athletes［J］. Addiction，98（9）：1249-1256. PETERSON A B，ABEL J M，LYNCH W J，2014a. Dose-dependent effects of wheel running on cocaine-seeking and prefrontal cortex Bdnf exon IV expression in rats［J］. Psychopharmacology，231（7）： 1305-1314. PETERSON A B，HIVICK D P，LYNCH W J，2014b. Dose-dependent effectiveness of wheel running to attenuate cocaine-seeking：impact of sex and estrous cycle in rats［J］. Psychopharmacology，231（13）： 2661-2670. RAWSON R A，CHUDZYNSKI J，MOONEY L，et al.，2015. Impact of an exercise intervention on methamphetamine use outcomes post-residential treatment care［J］. Drug Alcohol Depen，156：21-28. ROBERTS V，MADDISON R，SIMPSON C，et al.，2012. The acute ef￾fects of exercise on cigarette cravings，withdrawal symptoms，affect， and smoking behaviour：Systematic review update and meta-analysis ［J］. Psychopharmacology，222（1）：1-15. ROBISON L S，SWENSON S，HAMILTON J，et al.，2018. Exercise reduces dopamine D1R and increases D2R in rats：Implications for addiction［J］. Med Sci Sports Exer，50（8）：1596-1602. ROESSLER K K，2010. Exercise treatment for drug abuse - A danish