LODoos(family1)=log0(0.024/0039)=0g10(6.25)=0796 Same for families #2 and#3 2LoDo6( families1,2,3)=3x0.796=2388 Family #4 Maternal HD HDHD HD alleles SSR37 D D D D P if linked at 0.06=1/2(P if phase 1)+1/2(P if phase 2) =12(0.47X0.47X0.03X0.47)+1/2(0.03×0.03X0.47X003)=0.0016 ODo6eamy4)=log10(0.00160.0039)=0g10(0.41)=-0387log10 (0.024/0.0039) Same for families #2 and #3:
LOD0.06 (families 1, 2, 3) = 3 x 0.796 = 2.388 Family #4: SSR37 D D D D Maternal HD HD HD + HD alleles P if linked at 0.06 = 1/2 (P if phase 1) + 1/2 (P if phase 2) = 1/2 LOD0.06 (family 4) LOD0.06(family 1) = = log10 (6.25) = 0.796 (0.47 x 0.47 x 0.03 x 0.47) + 1/2 (0.03 x 0.03 x 0.47 x 0.03) = 0.0016 = log10 = log (0.41) 10 (0.0016/0.0039) = - 0.387