Pathophysiology Different organs may respond to different stimuli GI system: sensitive to inflammation, ischemia, spasm Insensitive to cutting heart sensitive to acute ischemia Integumentary stimuli at lowest level of intensity, evoke sensations of touch, pressure, warmth and cold Noxious stimuli increased to the point approaching tissue destruction, pain is addedPathophysiology •Different organs may respond to different stimuli GI system: sensitive to inflammation, ischemia, spasm insensitive to cutting heart: sensitive to acute ischemia •Integumentary stimuli at lowest level of intensity, evoke sensations of touch, pressure, warmth and cold •Noxious stimuli increased to the point approaching tissue destruction, pain is added