病毒学报 Research Progress on Human Immunodeficiency Virus Infection and Changes of Intestinal microbiome YU Zouzou, LI Yun", SONG Yinhong (1. Infection and inflammation Institute, Medical College, China Three Gorges University, Yichang 443002, China; 2. Dept. of cardiology People's Hospital of Yichang, Three Gorges University, Yichang 443000. China) Abstract: Human immunodeficiency virus(HIV) attacks CD4* T cell, leading to dysregulation of both the adaptive and innate immune. One of the main targets for viral infection is the intestinal tract which is a reservoir of CD4 T cells. Meanwhile, the human intestinal tract harbors trillions of commensal microorganisms, the mi- crobiota, which have recently been proved to play pivotal roles in health. Besides the direct role of HIV infec tion in altering the intestinal CD4* T cell compartment, HIV infection is able to change gut microbiota composi- tion and function. Here, we review these alterations and discuss their potential local and systemic effects on the individuals infected with HIV, as well as potential roles of novel microbiota- targeting treatments in regulating HIV progression and associated adverse systemic manifestations Key words: HIV; AIDS; Intestinal tract; Microbiota CD4 T cell Funding: The present work was supported by The National Natural and Science Fund(81671397)The study on driving thymic regeneration of the aged mice by a recombinant transcription factor fused with cell-penetrating peptide FOXNI-TAT and the corresponding mechanism of cells CorrespondingauthorsoNgYinhong.E-mail:syh728@126.com病 毒 学 报 Research Progress on Human Immunodeficiency Virus Infection and Changes of Intestinal Microbiome YU Zouzou1# ，LI Yun1,2# ，SONG Yinhong1* （1. Infection and inflammation Institute，Medical College，China Three Gorges University，Yichang 443002，China；2. Dept. of Cardiology， People's Hospital of Yichang，Three Gorges University，Yichang 443000，China） Abstract：Human immunodeficiency virus（HIV）attacks CD4+ T cell，leading to dysregulation of both the adaptive and innate immune. One of the main targets for viral infection is the intestinal tract which is a reservoir of CD4+ T cells. Meanwhile，the human intestinal tract harbors trillions of commensal microorganisms，the mi⁃ crobiota，which have recently been proved to play pivotal roles in health. Besides the direct role of HIV infec⁃ tion in altering the intestinal CD4+ T cell compartment，HIV infection is able to change gut microbiota composi⁃ tion and function. Here，we review these alterations and discuss their potential local and systemic effects on the individuals infected with HIV，as well as potential roles of novel microbiota- targeting treatments in regulating HIV progression and associated adverse systemic manifestations. Key words：HIV；AIDS；Intestinal tract；Microbiota；CD4+ T cell Funding：The present work was supported by The National Natural and Science Fund（81671397）The study on driving thymic regeneration of the aged mice by a recombinant transcription factor fused with cell-penetrating peptide FOXN1-TAT and the corresponding mechanism of cells and molecules ∗ Corresponding author ：SONG Yinhong，E-mail：syh728@126.com · 8 ·