Basic Terms Used in viral Genetics Genotype Genetic makeup of a virus a subpopulation of viruses of a virus species that share more homology with each other in nucleic acid sequence and/or amino acid sequence than with other subpopulations Patients infected with genotype b and c of hepatitis b virus respond to the treatment quite differently.Basic Terms Used in Viral Genetics z Genotyp e ¾ Genetic makeup of a virus ¾ A subpopulation of viruses of a virus species that share more A subpopulation of viruses of a virus species that share more homology with each other in nucleic acid sequence and/or amino acid sequence than with other subpopulations “Patients infected with genotype B and C of hepatitis B virus respond to the treatment quite differently