上游充通大 Simplified schematic of an immune response Shanghai Jiao Tong University proliferation differentiation CD8+T cells -CD8+cytolytic T cells Class I IFNy,IL-2 proliferation APC Class Il CD4+T cells differentiation CD4+immune cells Cytokines (delayed hypersensitivity Costim.Mol. L-4,-5,-6 Protein antigens B cells Plasma cells proliferation ↓ MHC class Il/peptides differentiation antibody APCs productionShanghai Jiao Tong University Simplified schematic of an immune response Class I MHC class II/peptides APCs Protein antigens CD8+ T cells CD4+ T cells B cells Plasma cells CD8+ cytolytic T cells CD4+ immune cells (delayed hypersensitivity) antibody production proliferation & differentiation IFNg, IL-2 Cytokines Costim. Mol. IL-4,-5,-6 proliferation & differentiation APC Class II proliferation & differentiation