Biochemistry of dioxin toxicity PCDD/Fs are planar aromatic molecules The planar structure allows them to bind to Ah(aryl hydrocarbon receptor protein that is present in all animal species. The ah receptor interacts with the cell s dna Dioxin toxicity is roughly proportional to the strength of binding to the ah receptor. This explains that 2378-TCDD is the most toxic oneBiochemistry of dioxin toxicity • PCDD/Fs are planar aromatic molecules. • The planar structure allows them to bind to Ah (Aryl hydrocarbon) receptor protein that is present in all animal species. • The Ah receptor interacts with the cell’s DNA. • Dioxin toxicity is roughly proportional to the strength of binding to the Ah receptor. • This explains that 2378-TCDD is the most toxic one